• Dr. Misfiqua

The goal is to investigate anticancer properties, identify and characterize selected chemical compounds, and test and evaluate the anticancer compound’s effects on cancer cells using cytotoxicity assays. and the possibility of developing a novel anticancer drug. The objective of this study was to investigate the anti proliferative activities of alkaloidal extract of Alangium Salvifolium leaves against MCF-7, MDA-MB-468 breast cancer cell lines. One of the most prevalent causes of disease-related deaths worldwide is cancer, known as the abnormal division, proliferation and accumulation of cells in an organism. Despite the discovery of many chemotherapeutic drugs (Adriamycin, Cisplatin, Campotins, Vinblastin, Mercaptopurine, etc.) that inhibit the uncontrolled process of cell division for the treatment of various types of cancer, the serious side effects of these drugs on the hematopoietic system, bone marrow, gastrointestinal epithelial cells and hair follicles are a significant disadvantage. In addition, multi-drug resistance (MDR) is another important problem in anticancer treatment. Previous studies have shown that many compounds obtained from natural resources may be used in cancer therapy as preventive and therapeutic agents. When used in combination with chemotherapy or alone in different cancer types, these compounds have been shown to increase the efficacy and tolerance of chemotherapy agents and can be effectively utilized as antitumour agents.

Breast cancer, apoptois, cytotoxicity assay, anti proliferative activity, alkaloidal extract.

" Cytotoxic activity of Alangium Salvifolium on human breast cancer cell lines MCF-7, MDA-MB-468.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 10, page no.f735-f739, October-2023, Available :http://www.jetir.org/papers/JETIR2310492.pdf

" Cytotoxic activity of Alangium Salvifolium on human breast cancer cell lines MCF-7, MDA-MB-468.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 10, page no. ppf735-f739, October-2023, Available at : http://www.jetir.org/papers/JETIR2310492.pdf