• MOHIT
• Dr. Arvind Rathour
• Dr. Ram kumar Roy

Abstract- An attempt to develop transdermal therapeutic system for Atorvastatin calcium using polymers like HPMC, EC, and ERS100 was carried out for the purpose of attaining maximum bioavailability by tress passing pre-systemic hepatic metabolism. The compatibility studies using TLC and IR spectral studies revealedthe absence of interaction between the drug and the polymer. The percentage moisture content and percentage moisture uptake is found to be high for the patches formulated with HPMC:EC when compared to the patches formulated with HPMC:ERS100 and EC:ERS100. The reason behind the screen might be the higher proportions of hydrophilic polymer, HPMC along with EC; whereas patches with HPMC:ERS100 combination shows lesser moisture content and moisture uptake because of the highly hydrophobic polymer, ERS100. For the patches with HPMC:EC tensile strength was found to be highand hardness was found to be low when compared to other patches which might be due to the nature of the polymers.All the patches showed uniform drug content. The formulations T8-T14 showed a better in vitro drug release profile across the cellulose membrane, when compared to the other formulations. This might be attributed to the nature of polymer; plasticizers used and even the permeation enhancer.

“FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES CONTAINING ATORVASTATIN CALCIUM AS A DRUG”

"“FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES CONTAINING ATORVASTATIN CALCIUM AS A DRUG”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 10, page no.f776-f782, October-2023, Available :http://www.jetir.org/papers/JETIR2310497.pdf

"“FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES CONTAINING ATORVASTATIN CALCIUM AS A DRUG”", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 10, page no. ppf776-f782, October-2023, Available at : http://www.jetir.org/papers/JETIR2310497.pdf