• Praveen Tripathi
• Dharmendra Kumar Sahu
• Monika Singh

A methanolic solution of 4-Chlorobenzoyl hydrazine, KOH and CS2 was stirred for 2 hours in ice water bath. A solid mass was obtained. It was refluxed with excess of hydrazine hydrate for 4 hours. This reaction mixture was cooled and poured into cold water and neutralised with dil. HCl. The compound 4-amino-5-(4-chlorophenyl)-3-mercapto-1,2,4-triazoles thus obtained was filtered and washed well with water and crystallised from aqueous ethanol. The compound 4-amino-5-(4-chlorophenyl)-3-mercapto-1, 2, 4-triazoles and 3,4-dimethyl phenyl Isocyanate was refluxed in DMF for 14 hours. After refluxing this mixture was poured into water. The compound 5-(4-chlorophenyl)-2-(3,4-dimethyl phenyl)-amino-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole thus precipitated out was filtered, washed with water dried and crystallised from aqueous ethanol. The final product have been characterized by spectral studies and screened for their fungicidal activities against two fungus Aspergillusniger and Helminthosporiumoryzae. The compound 3-(4-Chlorophenyl)-6-mercapto-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazolo was prepared by stirring 4-amino-5-(4-chlorophenyl)-3-mercapto-1,2,4-triazolo and carbon disulphide in methanol and KOH was added in this mixture and stirred for 6 hours. It was poured into water and neutralized by HCl. The compound have been screened for their fungicidal activity against four fungi Aspergillusniger, Helminthosporiumoryzae, Rhizoctoniasolani and Penicilliumcitrinum.

4-Chlorobenzoyl hydrazine, Synthesis, characterization, antifungal activity

"Synthesis and Fungicidal Activities of Some 5-Aryl-2-(3,4-dimethyl phenyl)-amino-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles and 3-Aryl-6-mercapto-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 11, page no.a610-a614, November-2023, Available :http://www.jetir.org/papers/JETIR2311075.pdf

"Synthesis and Fungicidal Activities of Some 5-Aryl-2-(3,4-dimethyl phenyl)-amino-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles and 3-Aryl-6-mercapto-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 11, page no. ppa610-a614, November-2023, Available at : http://www.jetir.org/papers/JETIR2311075.pdf