• Salunke Krupal Tulojirao
• Dr Uttam Kr Agarwal

Introduction: The first stage in creating dosage forms for any pharmacological ingredient is pre-formulation research. It verifies that the compound's development into a commercially available medication is not significantly difficult. Objective: The main objective of this research work was to conduct a pre-formulation analysis of Candesartan Cilexetil an angiotensin receptor blocker drug uses as antihypertensive medicine in order to produce a stable, robust including therapeutically effective system. Methods: Candesartan Cilexetil was analyzed to determine its physiochemical properties. Solubility was also determined in various pH-varying solvents and its purity was determined by FTIR and absorption maxima. Standard calibration curve was developed to aid in further analytical research studies. At last drug-excipients compatibility studies were performed. Results: Organoleptic properties indicated that the drug was almost white in color and odourless. The melting point was recorded at 158.2 ºC. The partition coefficient value log P was found to be 0.59±0.125. The purity of drug was confirmed by infrared spectrum which showed characteristics peaks and by UV spectroscopy which exhibited maxima at 257 nm. The standard curve obtained was linear with correlation coefficient (R2 =0.998) and equation y = 0.033 +0.012. There were no drug excipient interactions which was clear as no visual changes in drug samples were observed with respect to discoloration, liquefaction and odor. Conclusion: The powder blend under consideration was pure Candesartan Cilexetil which had good physiochemical property suggesting use of drug to formulation of novel drug such mouth dissolving tablet by various means and it was stable with selected excipient at reported ratio at 40oC / 75 % RH for 4 weeks.

Pre-formulation, Candesartan Cilexetil, excipients, flow property, FTIR

"Preformulation Studies of Candesartan Cilexetil: Initial Step towards Development of Mouth Dissolving Tablets ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 11, page no.a620-a629, November-2023, Available :http://www.jetir.org/papers/JETIR2311077.pdf

"Preformulation Studies of Candesartan Cilexetil: Initial Step towards Development of Mouth Dissolving Tablets ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 11, page no. ppa620-a629, November-2023, Available at : http://www.jetir.org/papers/JETIR2311077.pdf