• M Arun Kumar
• K. Srinivasa Reddy

Oral drug delivery is the most practical way and safest option for the administration of pharmaceuticals. liquid dosage forms, such as syrups and suspensions, are easy to swallow and show convenience to patient populations like pediatrics, geriatrics, and those with dysphagia but have the disadvantage of not being site-specific and having a limited gastric resident time. Alginate-based oral in-situ raft forming system approach can be used to overcome the disadvantages of conventional oral liquid drug delivery systems. The raft system is a type of gastro-retentive drug delivery system that improves the gastric retention time of the dosage form and improves the bioavailability of the drug. The formation of in-situ gel based on physiological stimuli, and physical, and chemical mechanisms from which the drug gets released in a sustained and controlled manner. Alginate is a natural hydrophilic polysaccharide polymer present in the cell wall of marine brown algae; the ion-responsive property of the alginate made it preferable in the selection of a gel-forming agent. This system involves in development of liquid dosage form either suspension or solution in the alginate solution along with inactive calcium ions. When the dosage form comes in contact with the acidic environment, the calcium ions get liberated from the system and react with alginate, leading to in-situ gelation. The resulting gel can be modified to float or perform muco-adhesion. This article will provide an overview of liquid oral sustained-release drug delivery systems, with a focus on formulations based on alginate.

Alginate, in-situ raft, gastro retentive, gastric retention time, bioavailability, sustained release, ion-responsive, calcium ions, float, muco-adhesion.

"System for Generating Oral In-Situ Rafts using Alginate", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 11, page no.b402-b407, November-2023, Available :http://www.jetir.org/papers/JETIR2311148.pdf

"System for Generating Oral In-Situ Rafts using Alginate", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 11, page no. ppb402-b407, November-2023, Available at : http://www.jetir.org/papers/JETIR2311148.pdf