• V. Jyoshna

Nephrotoxicity is defined as a sharp decline in kidney function brought on by the harmful effects of drugs and chemicals. There are several variations, and certain medications may have multiple effects on renal function. Substances that exhibit nephrotoxicity are known as nephrotoxins. Nephrotoxicity is caused by many mechanisms. Plant products have popularity in treating various diseases from ancient. The majority of alkaloids, particularly those with anti-inflammatory, anti-cancer, and anti-angiogenic properties, have definite biological effects that are frequently used in therapeutic contexts. The alkaloids Berberine and Ligustrazine have nephronprotective activity. The aim of the present study is to perform in silico docking studies for these alkaloids. The 3D sturcutres are collected from pubchem and the protein 3ANS collected from literature studies. Berberine, Ligustrazine, Standard (alpha tocoferol) was docked under 3ANS protein. The docking scores are -9.3,-9.1,-5.2 for standard, berberine and ligustrazine respectively. Thus berbeine has higher nephroprotection than ligustrazine. This study can help to treat various kidney diseases like Acute Kidney Disease, End Stage Renal Disease and other kidney diseases.

Nephrotoxicity, Alkaloids, Berberine, Ligustrazine, in silico docking, Nephroprotection

"IN SILICO DOCKING STUDIES FOR SELECTED ALKALOID COMPOUNDS FOR NEPHROPROTECTIVE ACTIVITY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 11, page no.b446-b453, November-2023, Available :http://www.jetir.org/papers/JETIR2311154.pdf

"IN SILICO DOCKING STUDIES FOR SELECTED ALKALOID COMPOUNDS FOR NEPHROPROTECTIVE ACTIVITY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 11, page no. ppb446-b453, November-2023, Available at : http://www.jetir.org/papers/JETIR2311154.pdf