• Deekshitha Nagendra
• Dr. Ekta Singh
• Dr. K Selvakumar
• Sameeksha A S

The efficacy of orally administered medications gets affected by multiple pharmacokinetic parameters. So, the technology involving transdermal delivery of medication was developed to enhance the pharmacokinetic qualities and overcome some of the disadvantages related to the oral route of administration. In this article, we have included the history of the transdermal drug delivery system, factors affecting drug permeation through the skin, advantages, limitations, and use in pediatrics and elderly patients. This review article compiles the different models of skin-on-a-chip for drug testing (human skin equivalent models and full-thickness skin equivalent models). The human skin equivalent model utilizes the technique of incorporating a biopsy of the skin. The in-situ skin-on-a-chip is about making the skin model directly in the chip. The most recent scientific research on the applications of skin-on-a-chip technology in drug diffusion studies has been discussed.

Transdermal drug delivery, skin on-a-chip model, drug analysis, Full-thickness skin equivalents, drug diffusion

"TRANSDERMAL PATCHES AND ‘SKIN-ON-A-CHIP’ MODEL: A REVIEW ON THEIR APPLICATIONS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 11, page no.b454-b468, November-2023, Available :http://www.jetir.org/papers/JETIR2311155.pdf

"TRANSDERMAL PATCHES AND ‘SKIN-ON-A-CHIP’ MODEL: A REVIEW ON THEIR APPLICATIONS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 11, page no. ppb454-b468, November-2023, Available at : http://www.jetir.org/papers/JETIR2311155.pdf