UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Volume 11 | Issue 10 | October 2024

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Volume 10 Issue 11
November-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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JETIR2311246


Registration ID:
527905

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c326-c340

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Title

DINUCLEAR COPPER(II) COMPLEXES WITH PENTADENTATE SCHIFF BASE LIGAND – SYNTHESIS, CHARACTERIZATION AND THEORETICAL EVALUATIONS

Abstract

The growth of Schiff base-centered medicinal chemistry, together with the usage of less costly transition metals having strong pharmacological activity, has sparked a lot of interest in the creation of new Schiff base ligands. A new pentadentate Schiff base ligand 2,6-bis((E)-(2-amino-4-methylphenylimino)methyl)-4-methoxyphenol (L1) was synthesized from 4-methyl-orthophenlylenediamine and 2,6-diformyl-4-methoxyphenol. Two distinct Cu(II) Complexes (C1 & C2) were prepared using this ligand and various cu(II) precursor with different organic acids. The structure of the obtained Schiff base ligand (L1) and Copper(II) complexes (C1 & C2) is clarified using a variety of analytical techniques, including electronic spectroscopy, Fourier transform infrared spectroscopy, 1H NMR, 13C NMR spectroscopy, mass spectrometry, conductivity and magnetic susceptibility studies, which demonstrated the pentadentate chelation of the ligand. Extensive physical and theoretical investigations of the ligand (L1) were performed, and the results were compatible with the expected compositions. The electrostatic potential surface was mapped with different parameters, the HOMO-LUMO band gaps and Mulliken charges were determined. The results of the experiments and the theoretical DFT analysis coincide well. In addition, the binding interaction between the human estrogen receptor and the breast cancer-induced protein (PDB:3ERT) was examined in a molecular docking study of the Schiff base ligand (L1) and their Cu(II) complex (C1).

Key Words

Schiff base ligand, DFT, HOMO – LUMO and Molecular Docking

Cite This Article

"DINUCLEAR COPPER(II) COMPLEXES WITH PENTADENTATE SCHIFF BASE LIGAND – SYNTHESIS, CHARACTERIZATION AND THEORETICAL EVALUATIONS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 11, page no.c326-c340, November-2023, Available :http://www.jetir.org/papers/JETIR2311246.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"DINUCLEAR COPPER(II) COMPLEXES WITH PENTADENTATE SCHIFF BASE LIGAND – SYNTHESIS, CHARACTERIZATION AND THEORETICAL EVALUATIONS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 11, page no. ppc326-c340, November-2023, Available at : http://www.jetir.org/papers/JETIR2311246.pdf

Publication Details

Published Paper ID: JETIR2311246
Registration ID: 527905
Published In: Volume 10 | Issue 11 | Year November-2023
DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.36831
Page No: c326-c340
Country: VELLORE, TAMILNADU, India .
Area: Chemistry
ISSN Number: 2349-5162
Publisher: IJ Publication


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