UGC Approved Journal no 63975(19)

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Volume 10 Issue 11
November-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2311278


Registration ID:
528083

Page Number

c567-c576

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Title

Formulation and Evaluation of Transdermal Films of Anti-depressant drug Sertraline using Eudragit E100, HPMC

Abstract

Transdermal drug delivery system (TDDS) was designed to sustain the release and improve the bioavailability of drug and patient compliance. The matrix type transdermal film of Sertraline was prepared by solvent evaporation method using two different polymers Eudragit E 100 & hydroxy propyl methyl cellulose (HPMC) in different ratios. Dibutyl phthalate was used as a plasticizer. The films were evaluated for physical properties such as thickness, percentage moisture absorption, percentage moisture loss, drug content, folding endurance and flatness. The in-vitro release studies were performed using USP dissolution apparatus. The optimized film was further evaluated for skin permeation, stability and skin irritation studies. The data obtained shows that the transdermal film F5 (Eudragit E 100 & HPMC at ratio of 2:1) had produced a highest drug release of 98 ±1.02% up to 24 hrs. When the release study was conducted for F5 on an animal skin there was a drastic decrease (61.56 ± 0.14%) in the percentage of drug release. The kinetics of drug release followed higuchi model with diffusion controlled mechanism. Skin irritation studies showed no sign of edema and erythema. There was no interaction found between the drug and polymer as proved by FTIR studies. The prepared film of Sertraline is found to provide a controlled release and permeation which is suitable for transdermal delivery.

Key Words

Transdermal Delivery, Sertraline, Hydroxy Propyl Methyl Cellulose, Eudragit E 100, In-vitro Evaluation, Skin Permeation

Cite This Article

"Formulation and Evaluation of Transdermal Films of Anti-depressant drug Sertraline using Eudragit E100, HPMC ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 11, page no.c567-c576, November-2023, Available :http://www.jetir.org/papers/JETIR2311278.pdf

ISSN


2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"Formulation and Evaluation of Transdermal Films of Anti-depressant drug Sertraline using Eudragit E100, HPMC ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 11, page no. ppc567-c576, November-2023, Available at : http://www.jetir.org/papers/JETIR2311278.pdf

Publication Details

Published Paper ID: JETIR2311278
Registration ID: 528083
Published In: Volume 10 | Issue 11 | Year November-2023
DOI (Digital Object Identifier):
Page No: c567-c576
Country: KANYAKUMARI, TAMIL NADU, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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