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Volume 10 Issue 11
November-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2311348


Registration ID:
528322

Page Number

d355-d363

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Title

An Update On Proton pump inhibitors in the treatment of peptic ulcer and gastroesophageal reflux disease

Abstract

Proton pump inhibitors (PPIs) have emerged as cornerstone therapeutic agents in the management of peptic ulcer and gastroesophageal reflux disease (GERD). This abstract provides a concise overview of the current status of PPIs in the treatment of these gastrointestinal disorders. Peptic ulcers, characterized by mucosal erosions in the stomach or duodenum, are commonly associated with Helicobacter pylori infection or nonsteroidal anti-inflammatory drug (NSAID) use. PPIs exert their therapeutic effects by inhibiting the gastric proton pump, thereby reducing acid secretion and promoting ulcer healing. The efficacy of PPIs in peptic ulcer treatment has been well-established through numerous clinical trials. In GERD, a chronic condition marked by the reflux of stomach acid into the esophagus, PPIs are employed to alleviate symptoms and prevent complications such as esophagitis and Barrett's esophagus. PPIs act by suppressing gastric acid production, promoting esophageal healing, and mitigating symptoms such as heartburn and regurgitation. Long-term use of PPIs in GERD is a subject of ongoing research, considering potential side effects and the risk of rebound acid hypersecretion upon discontinuation. While PPIs have demonstrated efficacy and safety in the short-term management of peptic ulcers and GERD, ongoing research explores their optimal duration of use, potential adverse effects, and the role of alternative treatment modalities. Additionally, individual patient characteristics and preferences should be considered when determining the most suitable therapeutic approach. In conclusion, proton pump inhibitors remain integral in the contemporary management of peptic ulcer and GERD, offering effective acid suppression and promoting mucosal healing. However, ongoing research is essential to refine treatment strategies, address long-term concerns, and explore alternative options for patients with specific needs or contraindications.

Key Words

1. Proton pump inhibitors 2. Treatment 3. Peptic ulcer 4. Gastroesophageal reflux disease (GERD) 5. Update

Cite This Article

"An Update On Proton pump inhibitors in the treatment of peptic ulcer and gastroesophageal reflux disease", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 11, page no.d355-d363, November-2023, Available :http://www.jetir.org/papers/JETIR2311348.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"An Update On Proton pump inhibitors in the treatment of peptic ulcer and gastroesophageal reflux disease", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 11, page no. ppd355-d363, November-2023, Available at : http://www.jetir.org/papers/JETIR2311348.pdf

Publication Details

Published Paper ID: JETIR2311348
Registration ID: 528322
Published In: Volume 10 | Issue 11 | Year November-2023
DOI (Digital Object Identifier):
Page No: d355-d363
Country: sambhajinagar, Maharashtra , India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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