• Dr. Gopalkrishana Haribhau Murhekar
• Supriya D. Belsare

Abstract: We report the synthesis and result of biological evaluation of newly designed Novel series of s - triazine derivative with substituted amines by microwave assisted method. The strategy involved the reaction of Cynuaric chloride with 2 - amino pyrazene in the presence of sodium carbonate and 1, 4 - dioxane to construct intermediate product. The intermediate 4, 6 – dicchloro - N - (pyridine-2-yl) - 1, 3, 5-triazine - 2-amine (1) was substituted with various substituted amines moieties to furnish the final 8 target compounds i.e. 2, 3, 5, 7, 8, 9, and 10 respectively. The synthesized compounds were characterized by different characterization techniques like IR, UV, Mass spectrometry, 1H NMR, 13C NMR. These compounds were screened for their Antimicrobial activity against three microbial species (Escherichia coli, Pseudomonas fluorescens and staphylococcus aureus), Antifungal activity against two fungal species (Aspergillus niger and Candida albicans) and Antiviral Activity against two viruses (Dengue and Hepatitis B.). Among the tested derivatives from diethyl amine (5) and methoxyamine (9) show the highest biological activity than the rest derivatives.

Keywords: 2 - amino pyrazine, 4,6-dicchloro- N- (pyridine-2-yl)-1,3,5-triazine-2-amine, 1,4-dioxane.

"MICROWAVE ASSISTED SYNTHESIS AND BIOLOGICAL STUDY OF SOME NOVEL S-TRIAZINE DERIVATIVES WITH SUBSTITUTED AMINES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 11, page no.f80-f100, November-2023, Available :http://www.jetir.org/papers/JETIR2311509.pdf

"MICROWAVE ASSISTED SYNTHESIS AND BIOLOGICAL STUDY OF SOME NOVEL S-TRIAZINE DERIVATIVES WITH SUBSTITUTED AMINES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 11, page no. ppf80-f100, November-2023, Available at : http://www.jetir.org/papers/JETIR2311509.pdf