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Published in:

Volume 10 Issue 11
November-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2311509


Registration ID:
528881

Page Number

f80-f100

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Title

MICROWAVE ASSISTED SYNTHESIS AND BIOLOGICAL STUDY OF SOME NOVEL S-TRIAZINE DERIVATIVES WITH SUBSTITUTED AMINES

Abstract

Abstract: We report the synthesis and result of biological evaluation of newly designed Novel series of s - triazine derivative with substituted amines by microwave assisted method. The strategy involved the reaction of Cynuaric chloride with 2 - amino pyrazene in the presence of sodium carbonate and 1, 4 - dioxane to construct intermediate product. The intermediate 4, 6 – dicchloro - N - (pyridine-2-yl) - 1, 3, 5-triazine - 2-amine (1) was substituted with various substituted amines moieties to furnish the final 8 target compounds i.e. 2, 3, 5, 7, 8, 9, and 10 respectively. The synthesized compounds were characterized by different characterization techniques like IR, UV, Mass spectrometry, 1H NMR, 13C NMR. These compounds were screened for their Antimicrobial activity against three microbial species (Escherichia coli, Pseudomonas fluorescens and staphylococcus aureus), Antifungal activity against two fungal species (Aspergillus niger and Candida albicans) and Antiviral Activity against two viruses (Dengue and Hepatitis B.). Among the tested derivatives from diethyl amine (5) and methoxyamine (9) show the highest biological activity than the rest derivatives.

Key Words

Keywords: 2 - amino pyrazine, 4,6-dicchloro- N- (pyridine-2-yl)-1,3,5-triazine-2-amine, 1,4-dioxane.

Cite This Article

"MICROWAVE ASSISTED SYNTHESIS AND BIOLOGICAL STUDY OF SOME NOVEL S-TRIAZINE DERIVATIVES WITH SUBSTITUTED AMINES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 11, page no.f80-f100, November-2023, Available :http://www.jetir.org/papers/JETIR2311509.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"MICROWAVE ASSISTED SYNTHESIS AND BIOLOGICAL STUDY OF SOME NOVEL S-TRIAZINE DERIVATIVES WITH SUBSTITUTED AMINES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 11, page no. ppf80-f100, November-2023, Available at : http://www.jetir.org/papers/JETIR2311509.pdf

Publication Details

Published Paper ID: JETIR2311509
Registration ID: 528881
Published In: Volume 10 | Issue 11 | Year November-2023
DOI (Digital Object Identifier):
Page No: f80-f100
Country: Amravati, Maharashtra, India .
Area: Chemistry
ISSN Number: 2349-5162
Publisher: IJ Publication


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