• Israel Babu B J

The bi-layered buccoadhesive tablets were formulated with different ratios of natural and modified polymers using Propranolol hydrochloride as a model drug to achieve optimum drug release with good bioadhesive properties. The modification of chitosan was achieved with acetaldehyde (polymer-I) and propionaldehyde (polymer-II) to form a Schiff base. Modification and compatibility confirmed by FR-IR and DSC analysis. Ethylcellulose was used to provide an impermeable cap to achieve unidirectional drug release. The tablets were evaluated by different physical parameters such as swelling index, moisture uptake, ex vivo bioadhesion strength, adhesion time, hardness and friability and in-vitro drug release studies. The prepared formulation followed zero order, first order and Fickian-type drug release kinetics.

bucoadhesive drug delivery system, Propranolol hydrochloride, modified chitosan, polymer-I, polymer-II.

"OPTIMIZING DRUG RELEASE: FORMULATION AND EVALUATION OF BI-LAYERED BUCCOADHESIVE TABLETS WITH MODIFIED POLYMERS FOR PROPRANOLOL HYDROCHLORIDE DELIVERY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 11, page no.f412-f425, November-2023, Available :http://www.jetir.org/papers/JETIR2311547.pdf

"OPTIMIZING DRUG RELEASE: FORMULATION AND EVALUATION OF BI-LAYERED BUCCOADHESIVE TABLETS WITH MODIFIED POLYMERS FOR PROPRANOLOL HYDROCHLORIDE DELIVERY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 11, page no. ppf412-f425, November-2023, Available at : http://www.jetir.org/papers/JETIR2311547.pdf