UGC Approved Journal no 63975(19)

ISSN: 2349-5162 | ESTD Year : 2014
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Published in:

Volume 10 Issue 11
November-2023
eISSN: 2349-5162

UGC and ISSN approved 7.95 impact factor UGC Approved Journal no 63975

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Published Paper ID:
JETIR2311547


Registration ID:
529065

Page Number

f412-f425

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Title

OPTIMIZING DRUG RELEASE: FORMULATION AND EVALUATION OF BI-LAYERED BUCCOADHESIVE TABLETS WITH MODIFIED POLYMERS FOR PROPRANOLOL HYDROCHLORIDE DELIVERY

Authors

Abstract

The bi-layered buccoadhesive tablets were formulated with different ratios of natural and modified polymers using Propranolol hydrochloride as a model drug to achieve optimum drug release with good bioadhesive properties. The modification of chitosan was achieved with acetaldehyde (polymer-I) and propionaldehyde (polymer-II) to form a Schiff base. Modification and compatibility confirmed by FR-IR and DSC analysis. Ethylcellulose was used to provide an impermeable cap to achieve unidirectional drug release. The tablets were evaluated by different physical parameters such as swelling index, moisture uptake, ex vivo bioadhesion strength, adhesion time, hardness and friability and in-vitro drug release studies. The prepared formulation followed zero order, first order and Fickian-type drug release kinetics.

Key Words

bucoadhesive drug delivery system, Propranolol hydrochloride, modified chitosan, polymer-I, polymer-II.

Cite This Article

"OPTIMIZING DRUG RELEASE: FORMULATION AND EVALUATION OF BI-LAYERED BUCCOADHESIVE TABLETS WITH MODIFIED POLYMERS FOR PROPRANOLOL HYDROCHLORIDE DELIVERY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 11, page no.f412-f425, November-2023, Available :http://www.jetir.org/papers/JETIR2311547.pdf

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2349-5162 | Impact Factor 7.95 Calculate by Google Scholar

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 7.95 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Cite This Article

"OPTIMIZING DRUG RELEASE: FORMULATION AND EVALUATION OF BI-LAYERED BUCCOADHESIVE TABLETS WITH MODIFIED POLYMERS FOR PROPRANOLOL HYDROCHLORIDE DELIVERY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 11, page no. ppf412-f425, November-2023, Available at : http://www.jetir.org/papers/JETIR2311547.pdf

Publication Details

Published Paper ID: JETIR2311547
Registration ID: 529065
Published In: Volume 10 | Issue 11 | Year November-2023
DOI (Digital Object Identifier):
Page No: f412-f425
Country: BHADRAVATHI, Karnataka, India .
Area: Pharmacy
ISSN Number: 2349-5162
Publisher: IJ Publication


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