• Mr. Vishal Bapu Patil
• Ms. Pooja makh
• Dr. Gajanan sanap sir

Many disorders affecting the hypothalamic-neurohypophyseal system can lead to central diabetes insipidus (CDI). Germininoma/craniopharyngioma, Langerhans cell histiocytosis (LCH), vascular, autoimmune, or local inflammatory diseases; trauma from surgery or an accident; sarcoidosis; metastases; and midline cerebral and cranial malformations are among the known causes. Rarely, X-linked recessive, autosomal dominant, or autosomal recessive genetic abnormalities in vasopressin synthesis may be the underlying cause. Given that the underlying condition requires long-term follow-up, the diagnosis is difficult and causes anxiety in both patients and parents. The process of achieving an accurate etiological diagnosis involves a number of steps, beginning with clinical observations and moving on to more advanced instruments. The most notable findings that have contributed to the diagnosis and understanding of neurohypophyseal functional integrity have been obtained specifically from the MRI identification of pituitary hyperintensity in the posterior part of the sella, which is now recognized as a clear marker of neurohypophyseal functional integrity, and the meticulous examination of pituitary stalk shape and size. If left untreated, diabetes insipidus, which is characterized by large amounts of diluted urine excretion, can be fatal. It can be brought on by one of two essentially distinct defects: either impaired or insufficient renal response to ADH (nephrogenic diabetes insipidus) or inadequate or impaired secretion of antidiuretic hormone (ADH) from the posterior pituitary gland (neurogenic or central diabetes insipidus). Making the distinction is necessary for treatment to be effective. Antidiuretic hormone (ADH), a posterior pituitary peptide hormone, is involved in diabetes insipidus.

Central diabetes insipidus _ Langerhans cell histiocytosis _Pituitary stalk _ Vasopressin central diabetes insipidus.

"Review On Diabetes Insipidus", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 12, page no.g47-g57, December-2023, Available :http://www.jetir.org/papers/JETIR2312608.pdf

"Review On Diabetes Insipidus", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 12, page no. ppg47-g57, December-2023, Available at : http://www.jetir.org/papers/JETIR2312608.pdf