• Rajkumar.P.Ade
• A.S.Pratapwar
• Amle V.S
• Vivek K Pawar

In Present study, a microemulsion based gel (emulgel) system was constructed for transdermal delivery of ibuprofen. The formulations consists of oleic acid 6%, tween 80 20%, ethanol 10%, water phase 59% (w/w) and ibuprofen 5%, with different gelling agents i.e. Carbopol 934, HPMC K15M, Xanthun gum in 1% & 1.5% respectively. Similarly in the study, topical emulgels of ibuprofen were formulated and subjected to physicochemical studies i.e. pH, rheological studies, spreading coefficient & extrudability studies, skin irritation study, in vitro release studies, anti-inflammatory study. In vitro release of the tests formulations were performed to determine drug release from emulgel rate and duration of drug release. Formulated emulgel showed acceptable physical properties, drug content, drug release, and anti-inflammatory activity, which remained unchanged upon storage for 3 months. The physical appearance was milky white, pH was in between 6-6.5, formulations showed better spreading coefficient & extrudability. However, the Carbopol 934 based Emulgel in its low concentration with the formulation code F2 proved to be the formula of choice, since it showed Viscosity of the optimized batch F2 was found to be 26687 cps and 93.69% drug content, the highest drug release i.e. 87.45% in 6 hrs and incase of albumin induced paw edema it showed very good anti-inflammatory activity.

Emulgel, Rheological studies, spreading coefficient, Carbopol 934, transdermal delivery

"Formulation and Characterization of an Emulgel for Topical delivery of Hydrophobic Drug.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.10, Issue 12, page no.h162-h174, December-2023, Available :http://www.jetir.org/papers/JETIR2312720.pdf

"Formulation and Characterization of an Emulgel for Topical delivery of Hydrophobic Drug.", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.10, Issue 12, page no. pph162-h174, December-2023, Available at : http://www.jetir.org/papers/JETIR2312720.pdf