• kakade sujit baban
• JADHAV ABHISHEK RAOSAHEB
• JADHAV PAYAL ANIL
• RAYKAR MEGHANA

Drug which have slender absorption window in the gastrointestinal tract (GIT) may have bad absorption. For these drugs, gastroretentive drug shipping structures provide the benefit in prolonging the gastric emptying time. Famotidine belongs to H2-receptor antagonist. It is used extensively for the remedy of remedy of gastro-esophageal reflux disease (GERD) and gastric ulceration duodenal ulcer, pressure ulcer. The low bioavailability (40-45 %) and brief organic half-life (2.5-4.zero hrs ) of Famotidine following oral management favours improvement of a sustained launch formulation. The rapid gastrointestinal transit should bring about incomplete drug launch from the drug shipping device above the absorption zone main to bad bioavailability of the drug. The floating tablets have been formulated the use of artificial polymer like HPMC K15M and herbal polymer like chitosan as the discharge retardant polymers, and sodium bicarbonate because the fueloline producing agent to lessen the floating lag time. The reason of this research turned into to put together floating drug shipping device of famotidine. Famotidine having bad absorption in acidic environment (top GIT). When given orally, it indicates the bioavailability close to 50%. To triumph over those drawbacks, the presentlook at turned into undertaken to research the floating dosage shape of famotidine. Floating pills have been organized the use of Direct Compression. Six formulations have been organized containing gel-forming agent (HPMC K15M) and retardant (Na-CMC) in unique ratio and it turned into found that fueloline producing agent (NaHCO3) reacts with HCL and liberates CO2 which creates pores in pill and elevates swelling and maintains buoyancy. The organized pills have been evaluated for content material uniformity, hardness, friability, buoyancy, swelling index and in-vitro dissolution research. Further decided on formula turned into subjected for brief time period balance research for one and month at temperature of 25°c and 40°c respectively.

Gastroretentive drug shipping system, Floating Tablet, Famotidine, HPMC K15M, Chitosan famotidine,HPMC K one hundred M, Ethyl Cellulose, in vitro buoyancy, Direct Compression, in-vitro dissolution studies

"Formulation and evaluation of floating tablets of famotidine", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 1, page no.e271-e277, January-2024, Available :http://www.jetir.org/papers/JETIR2401432.pdf

"Formulation and evaluation of floating tablets of famotidine", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 1, page no. ppe271-e277, January-2024, Available at : http://www.jetir.org/papers/JETIR2401432.pdf