• Parmeshwar A Haran
• Atul S Pratapwar
• Manisha M Thakre
• Anand R Haran

ABSTRACT: These days various developed and developing countries goes towards a combination therapy for prevention of various diseases and disorders requiring long term therapy such as hypertension, diabetes and cardiovascular diseases. About 90% of the preparations, formulated today are ingested orally. It shows that bilayer tablet is popular worldwide and major attention of researchers is towards this directions. Bilayer tablet is a novel technique for the successful development of controlled release of formulation as well as various characteristics to provide a way of successful drug delivery system. Bilayer tablet can be a better option to reduce chemical incompatibilities taking place between active pharmaceutical ingredient and to enable the development of various drug release profile. Bilayer tablet are appropriate for the sequential release of two drugs to be given combined. It separates the two mismatching drugs. The sustained release tablets whose one layer provides instant drug release as a initial loading dose while the second layer contains the sustained dose. Bilayered tablet is improved beneficial technology to overcome the short coming of single layered tablet. Bilayer tablet prepared by using different technique such as OROS push pulls technology, L OROS technology, EN SO TROL technology. This systemic review explains about various techniques of bilayer tablet, ideal characteristics of bilayer tablet, various types of bilayer tablet, and the method of preparation of bilayer tablets, challenges in manufacturing of bilayer tablets, and the evaluation of bilayer tablets. There are various applications of bilayer tablets which consist of monolithic partially coated or multilayered matrices.

Bilayer tablets, OROS technology, Fixed dose combination, Sustained release, Immediate release layer.

"BILAYER TABLET : AN DUAL RELEASE DRUG DELIVERY SYSTEM ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 1, page no.h161-h169, January-2024, Available :http://www.jetir.org/papers/JETIR2401715.pdf

"BILAYER TABLET : AN DUAL RELEASE DRUG DELIVERY SYSTEM ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 1, page no. pph161-h169, January-2024, Available at : http://www.jetir.org/papers/JETIR2401715.pdf