• Sreerama Chandra Murthy Babburi
• Bhupathi Naidu Gajula
• Sujidurga Mareeswsaran
• Abdul Razak Cherukuri
• Ameem Shaik

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multisystem involvement. It is multifactorial and involves genetic, ecological, and environmental factors. Primarily it leads to activation of both innate and adaptive immunity, which consequently leads to B cell activation by T cells and leads to immune complexes deposition in tissues leading to an autoimmune cascade that may be limited to the single organ or can cause a widespread systemic involvement. SLE is heterogeneous in presentation, with a broad spectrum of clinical manifestations ranging from clinically mild self-resolving symptoms to severe life-threatening organ involvement. Clinical and serological heterogeneity are critical features in SLE. Complex pathogenesis involves multiple cellular components of the innate and immune systems, presence of autoantibodies and immunocomplexes, complement system, dysregulation of several cytokines includes type I interferons, and disruption of the clearance of nucleic acids after cell death. Use of immunomodulators and immunosuppression has altered the course of SLE. Morbidity and mortality in SLE not only derive from direct immune mediated tissue damage but also from SLE and treatment associated complications such as accelerated coronary artery disease and increased infection risk. Here, we review the diagnostic approach as well as the etiopathogenetic and clinical evidence for the management of SLE. This includes 1) lifestyle changes such as avoidance of ultraviolet light 2) prevention of comorbidities including coronary artery disease, osteoporosis, infections, and drug toxicity 3) use of immunomodulators (Hydroxychloroquine and vitamin D) 4) Immunosuppressants and targeted therapy. We review new upcoming agents and regimens currently under study.

Fever, Hydroxychloroquine, Methotrexate, T and B cells, Hemolysis, Antibody against nucleus

"Narrative Review on Systemic Lupus Erythematosus", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 2, page no.a79-a89, February-2024, Available :http://www.jetir.org/papers/JETIR2402010.pdf

"Narrative Review on Systemic Lupus Erythematosus", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 2, page no. ppa79-a89, February-2024, Available at : http://www.jetir.org/papers/JETIR2402010.pdf