• Roma Sharma
• Dr. Surabhi Singh

The SARS-CoV-2 pandemic was a grave concern worldwide. It was posing a serious threat to mankind and was acting as a global threat with no effective treatment. There was no definite therapy available and globally it was a challenge to decide on ways to prevent it from spreading. The scientific community was working on all fronts to decide on a single solution to curb the situation at the earliest. The viral infection bourgeons and affects the life score in one form or the other. The biomarkers were limitedly studied as it was not established that they help in identifying poor prognosis in COVID-19 cases. The study of Novel Biomarkers was prioritized in those challenging times. During that time when the viral journey was exponentially increased studies were released on Neopterin (NPT) and it was established that neopterin is one biomarker that signals an active immune system and is a promising tool to detect the severity and prognosis of COVID-19. The objective of this review is to find Neopterin's utility for the diagnosis and prognosis of SARS-CoV-2 infection. The research was comprehensively performed by using databases like Cochrane, PubMed, Scopus, and EMBASE. A total of six out of seven research literature were included for the initial screening of this review. Captivatingly, all studies reported that serum NPT levels were high in all severe cases and the NPT levels were positively correlated with the COVID-19 infection. This study provides the existing evidence through a meta-analysis of relevant studies where it provides a detailed analysis of Neopterin as a potential biomarker. For the best results, PRISMA guidelines were followed. This implies that makeshift can be done using serum NPT levels before hospital admission to determine the severity and prognosis of the disease which helps in close monitoring of such cases with risk stratification for better management in a highly populated country.

Neopterin, SARS-COV-2, ACE 2, Prognosis, Biomarker

"A Comprehensive Analysis of Neopterin as a Prognostic Marker for SARS-CoV-2 Patients", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 2, page no.a224-a233, February-2024, Available :http://www.jetir.org/papers/JETIR2402026.pdf

"A Comprehensive Analysis of Neopterin as a Prognostic Marker for SARS-CoV-2 Patients", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 2, page no. ppa224-a233, February-2024, Available at : http://www.jetir.org/papers/JETIR2402026.pdf