• K. Varalakshmi
• D. Krishti
• S. Divyasri
• K. Bhargavi
• Dr. Anila Patibandla, Dr. Purushothama Reddy K, Dr. K. Padmalatha

Cytotoxic chemotherapy suppresses the hematopoietic system, impairing host protective mechanisms and limiting the doses of chemotherapy that can be tolerated. Neutropenia, the most serious hematologic toxicity, is associated with the risk of life-threatening infections as well as chemotherapy dose reductions and delays that may compromise treatment outcomes. Chemotherapy induced late onset neutropenia, despite its importance as the primary dose-limiting toxicity, much concerning neutropenia and its consequences and impact remains unknown. Recent surveys indicate that neutropenia remains a prevalent problem associated with substantial morbidity, mortality and costs. Rituximab can cause late-onset neutropenia that may result in serious life-threatening complications. Much research has sought to identify risk factors that may predispose patients to neutropenic complications, including febrile neutropenia, in an effort to predict better which patients are at risk and to use preventive strategies, such as prophylactic colony-stimulating factors, more cost-effectively. Neutropenic complications associated with myelosuppressive chemotherapy are a significant cause of morbidity and mortality, possibly compromised treatment outcomes and excess healthcare costs. Research in quantifying the risk of neutropenic complications may make it possible in the near future to target patients at greater risk with appropriate preventive strategies, thereby maximizing the benefits and minimizing the costs.

Chemotherapy Induced Neutropenia (CIN), Risk Factors, Rituximab induced late-onset neutropenia, Colony-Stimulating Factors

"Chemotherapy Induced Neutropenia: A Case Series ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 2, page no.a650-a657, February-2024, Available :http://www.jetir.org/papers/JETIR2402084.pdf

"Chemotherapy Induced Neutropenia: A Case Series ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 2, page no. ppa650-a657, February-2024, Available at : http://www.jetir.org/papers/JETIR2402084.pdf