• Dr. P. J. Bindu
• Dr. T. R. Ravikumar naik

A series of substituted oxime esters have been synthesized and tested for their anticancer, antibacterial, DNA photocleavage and molecular docking studies. The in-house synthesized oxime esters were characterized by IR, 1H NMR, and mass spectra. Most of oxime esters showed good antibacterial and anticancer activity. All these compounds were found to cleave DNA upon irradiation with 365 nm UV light. The results indicated that oxime esters underwent homolysis of their weak N-O bonds on direct and photosensitized UV photolysis to afford iminyl and carboxy radicals which can then cause the cleavage of the pUC 19 DNA. A plausible reaction mechanism is also proposed. The interaction of between DNA protein with oxime esters was also evaluated by CT-DNA binding and molecular docking studies.

Oxime esters, Antibacterial, Anticancer, DNA photocleavage, DNA binding, Molecular docking

"Anticancer Potential of Biocompatible Oxime Esters; Synthesis, anticancer, antibacterial, DNA binding, DNA photocleavage and molecular docking studies ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 2, page no.b1-b20, February-2024, Available :http://www.jetir.org/papers/JETIR2402101.pdf

"Anticancer Potential of Biocompatible Oxime Esters; Synthesis, anticancer, antibacterial, DNA binding, DNA photocleavage and molecular docking studies ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 2, page no. ppb1-b20, February-2024, Available at : http://www.jetir.org/papers/JETIR2402101.pdf