• Aslam
• Muhammad Zishan
• Kajal Sherawat
• Ritu Verma
• Km. Shiva

7–10% of individuals throughout the world suffer from one of the prevalent mental diseases known as anxiety disorders. An excellent animal model for comprehending anxiety-related behavior is the zebrafish. They are most commonly employed to test different anxiety medications and investigate the neurological, physiological, and genetic causes of anxiety. To study and analyses the zebrafish model for anxiolytic activity utilities, benefits in comparison animal and other delicious facts about zebrafish model. We have looked through the literature to find several techniques for inducing anxiety in adult zebrafish using physical (like use of light and temperature, vibration or "tapping, Restrain, magnetic stress, shallow water etc.), mechanical (through glass rods to disturbing swimming behavior, separation, etc.), and chemical stimuli (induce anxiety though anxious chemical like Benzo[a]pyrene, alarm substance etc.). This review also focuses on finding the best ways to make adult zebrafish anxious without significant causality and at a reasonable price. In this review, we also explain these processes that someone common pathology followed. This analysis also covers some of the most popular conventional drugs and herbal anxiety remedies and some popular standard drugs use in market. In the last we explained some specific and commonly used behavioral model for observing behavioral parameter of anxiety. In Summary, zebrafish model are very demanding and most specific model to investigate anxiety like behavior and anxiety evoking for chemical induced anxiety, environmental stressors, anxiety inducing drugs, including novelty, and environmental toxin, mechanical stressor. This review was aimed to evaluate anxiety potential in a zebrafish model by induction by different stressor, which included neuro pharmacological evaluation to determine behavioral parameters in the novel tank diving test (NTDT), light-dark test (LDT), and Open field test. Similar to cortisol, anxiety-related neuroendocrine responses in zebrafish are likewise robust, responsive, and significantly (and symmetrically) correlated with behavioral outcomes. Overall, data demonstrates the reliability and effectiveness of the adult zebrafish model for researching both acute and long-term anxiety-like states.

Zebrafish, Anxiety, Stressor, Plant drug, Behavioral parameter.

"A REVIEW ARTICLE: FROM TO SERENITY: ZEBRAFISH AS A MODEL SYSTEM FOR ANXIOLYTIC INVESTIGATIONS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 2, page no.b250-b266, February-2024, Available :http://www.jetir.org/papers/JETIR2402126.pdf

"A REVIEW ARTICLE: FROM TO SERENITY: ZEBRAFISH AS A MODEL SYSTEM FOR ANXIOLYTIC INVESTIGATIONS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 2, page no. ppb250-b266, February-2024, Available at : http://www.jetir.org/papers/JETIR2402126.pdf