• B. Jeshma Kalyani
• SK. Sushma Taj
• K. Navaneetha
• M. Deepika
• K. Jahnavi

The 3D structures that can replicate in - vivo organs and in -vitro are called Organoids. Cell lines like that are pluripotent or mature cell can be used to create these organoids. In the past decades since organoid research is going on mainly through isolation and reorganization of cells. Research on organoids traced back as far as 1907. Due to recent developments in organoid technology, strong three- dimensional (3D) models that accurately replicate the cellular heterogeneity, structure and functions of primary tissues have transformed the in- vivo culture tools for biomedical research. With the ability to replicate human organs and disorders in a dish, organoid technology has enormous potential for a variety of translational applications, including precision medicine, drug discovery and regenerative medicine. Organoid culture is an emerging 3D technology and organoids derived from various organs and tissues such as brain, lung, liver and kidney as being generated. Process of developing organoids, elements of the engineering process of organoids such as cell source, matrix, soluble ingredients, integrating cues and physical cues, it encompasses significant occasions in the evolution of organoids. Methods of organoids and information on 3D models, organoid applications and advantages over the 2D models are being studied in terms of their strengths and limits are included in this article.

Organoids, Pluripotent stem cells, Adult stem cells, 3D models, Organoid Culture

"ORGANOIDS: A REVIEW ON ITS CREATION AND APPLICATIONS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 2, page no.b474-b485, February-2024, Available :http://www.jetir.org/papers/JETIR2402154.pdf

"ORGANOIDS: A REVIEW ON ITS CREATION AND APPLICATIONS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 2, page no. ppb474-b485, February-2024, Available at : http://www.jetir.org/papers/JETIR2402154.pdf