• SUNIL FIRANGI
• Dr. S.N.Hiremath

Abstract: The drug Ritonavir belongs to class IΙ under BCS, widely prescribed as antiviral drug in the treatment of HIV/AIDS, exhibit low and variable oral bioavailability because it is practically insoluble in water and aqueous fluids and as such it possesses challenging problems in its formulation development. This work was an attempt to increase therapeutic efficacy, reduce the frequency of drug administration, improve the bioavailability and patient compliance by developing Floating Ritonavir tablets for controlled release and to increase gastric retention time. The Floating Ritonavir tablets were prepared by wet granulation technique by using different ratios of HPMC K4M, Xanthan gum using PVP K30, Magnesium sterate, talc, sodium bicarbonate, citric acid, lactose, Sodium Alginate & Cross carmellous sodium. The prepared tablets were subjected to post compressional parameters such as hardness, weight variation, thickness, diameter, drug content, lag time, buoyancy time & invitro dissolution studies. Compatibility of the drug with excipients used was checked by FTIR studies. The stability studies were conducted as per ICH guidelines. In all the formulations, hardness test indicated good mechanical resistance. Sodium bicarbonate was added as a gas generating agent, induced carbon dioxide generating in presence of dissolution medium (0.1N HCl). The combination of sodium bicarbonate & citric acid provided desired floating ability.

Ritonavir, HPMC, Xanthan gum, Floating Drug Delivery, FTIR

"DESIGN, OPTIMIZATION AND INVITRO EVALUATION OF FDDS OF RITONAVIR TABLETS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 2, page no.d171-d181, February-2024, Available :http://www.jetir.org/papers/JETIR2402322.pdf

"DESIGN, OPTIMIZATION AND INVITRO EVALUATION OF FDDS OF RITONAVIR TABLETS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 2, page no. ppd171-d181, February-2024, Available at : http://www.jetir.org/papers/JETIR2402322.pdf