• Ummy Salma Munni
• Dr Khaleda Islam

Background: Proteinuria is central to the diagnosis of PE, and it is an important marker of the severity of the progression of the disease. There are several methods of detecting proteinuria, but controversies still exist regarding the most appropriate technique to be used. Moreover, the methods used in our hospitals are still crude in most cases. Aims: The present study was undertaken to compare the methods used for detection of proteinuria. Methods: 58 primigravida subjects, aged 17–35 years, with PE were studied along with 100 healthy pregnant women. PE was diagnosed by standard criteria, and proteinuria was measured by heat coagulation (HC), dipstick, sulphosalicylic acid (SSA), protein-creatinine ratio (UPr/Cr), and albumin-creatinine ratio (Alb/Cr). The significance of the difference between proportions and medians was measured by the McNemar chi-square test and the Mann-Whitney test, respectively. Results: While all the 100 cases in controls were negative for HC (by definition), there was a significant difference between HC and other tests in the control group. Dipstick detected 2 (χ2=4.5, p<0.05), SSA detected 3 (χ2=5.33, p<0.05), UPr/Cr ratio 5 (χ2=7.2, p<0.01), and Alb/Cr ratio 8(χ2=10.125, (p<0.01) positive cases in the control group. In the case of PE dipstick, SSA and the Alb/Cr ratio gave equivalent results. HC was positive in all the 58 cases, but dipstick and SSA detected 41 case (χ2=15.06, p<0.001), and Alb/Cr ratio 42 (χ2=14.06, p<0.001) positive cases. The difference of HC test and SSA with UPr/Cr ratio was statistically significant (χ2=27.03, p<0.001; χ2=5.5, p<0.02). When the microalbuminuria range was considered, the Alb/Cr ratio gave additional positive finding in 13 cases of Control and 5 in PE group. Conclusion: Dipsticks or SSA should be practiced, which seem to measure albumin accurately, as evident from their equivalence with the Alb/Cr ratio. But the UPr/Cr ratio is a better choice, probably due to its capacity to include non-albumin proteins. Key words: Proteinuria, PE, Dipstick methods, SSA

Proteinuria, PE, Dipstick methods, SSA

"Comparison of Different Methods to Detect Proteinuria in Normal and Pre-eclamptic Pregnancy", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 2, page no.e541-e548, February-2024, Available :http://www.jetir.org/papers/JETIR2402478.pdf

"Comparison of Different Methods to Detect Proteinuria in Normal and Pre-eclamptic Pregnancy", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 2, page no. ppe541-e548, February-2024, Available at : http://www.jetir.org/papers/JETIR2402478.pdf