• KRITIKA BADOLA
• Dr. G. Gnanarajan

The current work emphasises the significance of esomeprazole magnesium trihydrate floating polymeric microsphere formulation and assessment. EMT containing microspheres were successfully made using the solvent evaporation process using polymers EC & HPMC and ethanol with dichloromethane in 1:1 ratio as an organic solvent. Drug polymer compatibility was checked using FTIR and a standard curve of EMT was obtained using ethanol as solvent. The prepared formulations were then assessed for various evaluation characteristics. The best prepared formulation F3 showed % entrapment efficiency 79.98%, percentage yield of 81.7%, buoyancy study 83%, drug content 83.19%. Thereby, it could be concluded that EMT microspheres may be able to reduce the frequency of administration as well as the dosedependent adverse effects. There was no drug-polymer interaction discovered, and formulations remained stable over time. Thus, floating microspheres of EMT with good buoyancy and sustained release were obtained.

"FORMULATION AND EVALUATION OF FLOATING MICROSPHERES OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 2, page no.g354-g363, February-2024, Available :http://www.jetir.org/papers/JETIR2402645.pdf

"FORMULATION AND EVALUATION OF FLOATING MICROSPHERES OF ESOMEPRAZOLE MAGNESIUM TRIHYDRATE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 2, page no. ppg354-g363, February-2024, Available at : http://www.jetir.org/papers/JETIR2402645.pdf