• M. Bhavana Annie Chand
• Dr. K. Nagalakshmi
• M. Prasad Rao
• P Y V Kameswara Rao

A woman's quality of life may be greatly impacted by the range of symptoms that are frequently associated with menopause, a biological process that occurs naturally in her life. One synthetic progestin that has been investigated as a possible treatment for menopausal symptoms is norethisterone. The goal of this review is to give a thorough summary of all the negative effects related to using norethisterone to treat menopause. Results from observational research, clinical trials, and pertinent literature published up to the knowledge cutoff date of January 2022 are included in the review. The main focus is on the physiological and psychological negative effects that women taking norethisterone throughout menopause encounter. Changes in lipid profiles, breast discomfort, and menstrual patterns are examples of physiological adverse effects. Furthermore, the effects of norethisterone on metabolic parameters, cardiovascular health, and bone health are investigated. Mood swings, anxiety, and depression are examples of psychological side effects that are covered, recognizing the intricate relationship between hormone changes and mental health. The review also emphasizes the possible hazards of long-term Norethisterone usage, such as an elevated risk of thromboembolic events, some malignancies, and other cardiovascular issues. The safety profile and tolerability of norethisterone may be impacted by a number of factors, including age, health, and individual features in women.

Menopause, Norethisterone, Menopausal symptoms, Progestin, Side effects, Hormone therapy, Physiological effects, psychological effects, Clinical trials, Observational studies, Quality of life, Bone health, Cardiovascular function, Metabolic parameters, Cancer risk, Thromboembolic events, Individualized treatment, Healthcare communication, Women's health, Long-term effects.

"A Review on Side-effects by using Norethisterone to stop/delay menopause ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 2, page no.g364-g373, February-2024, Available :http://www.jetir.org/papers/JETIR2402646.pdf

"A Review on Side-effects by using Norethisterone to stop/delay menopause ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 2, page no. ppg364-g373, February-2024, Available at : http://www.jetir.org/papers/JETIR2402646.pdf