• Sabahat Quereshi
• Vikrant Jain

Pyrazole derivatives represent a class of compounds with growing importance in medicinal chemistry due to their diverse pharmacological activities, including anti-inflammatory properties. In this study, we synthesized and evaluated the anti-inflammatory effects of three pyrazole derivatives: Compound I, 1,5-diphenyl-4-(phenylselanyl)-1H-pyrazole; Compound II, 5-phenyl-4-(phenylselanyl)-1-(4-(trifluoromethyl)phenyl)-1H-pyrazole; and Compound III, 1-(3-chloro-4-fluorophenyl)-5-phenyl-4-(phenylselanyl)-1H-pyrazole. These compounds were synthesized using a one-pot-multicomponent synthesis approach, which offers efficiency and versatility in accessing structurally diverse compounds. The anti-inflammatory potential of these pyrazole derivatives was evaluated through a series of in vitro and in vivo experiments. Notably, all three compounds demonstrated significant anti-inflammatory activity. They effectively inhibited protein denaturation, a key process in inflammation-related diseases, and exhibited robust free radical scavenging abilities, as demonstrated by DPPH and ABTS assays. These findings suggest that these pyrazole derivatives may act as potent anti-inflammatory agents, holding promise for therapeutic applications in conditions characterized by inflammation and oxidative stress. Furthermore, an ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) analysis was conducted to assess the drug-like properties of these compounds. The results revealed favorable ADMET profiles, indicating good potential for absorption, distribution, metabolic stability, and reduced toxicity, all crucial factors in the development of pharmaceutical agents. In conclusion, our study highlights the anti-inflammatory effects of these synthesized pyrazole derivatives and their favorable ADMET profiles, making them promising candidates for further development as anti-inflammatory drugs. Their ability to mitigate inflammation-related processes, coupled with their drug-like characteristics, underscores their potential therapeutic relevance. Future research should focus on elucidating their mechanisms of action, conducting preclinical studies, and exploring their clinical applications as novel anti-inflammatory agents. These compounds offer new avenues for addressing inflammation-related disorders and represent a significant contribution to the field of medicinal chemistry and drug discovery.

Pyrazole derivatives, Anti-inflammatory effects, One-pot-multicomponent synthesis, Protein denaturation inhibition, ADMET analysis, Free radical scavenging, Drug-like properties.

"Anti-inflammatory effects and ADMET analysis of pyrazole derivatives", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 3, page no.b764-b773, March-2024, Available :http://www.jetir.org/papers/JETIR2403189.pdf

"Anti-inflammatory effects and ADMET analysis of pyrazole derivatives", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 3, page no. ppb764-b773, March-2024, Available at : http://www.jetir.org/papers/JETIR2403189.pdf