• Prasannjeet S. Bhopale
• Priyanka J. Anbhule
• Aditi S. Awati
• Sagar L. Chavan
• Rutuja J. Patil

Acetylsalicylic acid (ASA) is widely used globally to treat pain, rheumatic fever, and inflammation for over a century. It is also a prototypical molecule classified as a platelet aggregation inhibitor that could be widely used to minimize the risk of arterial and venous thrombosis in long-term therapy. There are numerous ASA formulations on the market and estimation of their quantity and efficacy is of utmost importance since it is largely being produced by many pharmaceutical companies all over the world. Literature is supported by many analytical methods using UV-visible spectrophotometer, liquid chromatography, liquid chromatography integrated with mass spectrometer (Lc-MS), UHPLc-MS/MS, Gas chromatography, electrochemical and titrimetric methods. In this study, an attenuated total Reflectance Fourier transform Infrared Spectroscopy (ATR-FTIR) method was developed for the estimation of ASA. The calibration curve was constructed on peak height location in the range of 2200-2500 cm-1 in the concentration range from 1-10µg/Ml with a correlation coefficient of 0.965. This new method was used for the quantification of ASA in tablets. During the spectral examination, excipients in the tablet formulation did not significantly interfere with the results.

Aspirin, quantification, FTIR spectroscopy, assay

"Quantitative Analysis of Pharmaceutical Using FTIR Spectroscopy", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 3, page no.c225-c234, March-2024, Available :http://www.jetir.org/papers/JETIR2403230.pdf

"Quantitative Analysis of Pharmaceutical Using FTIR Spectroscopy", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 3, page no. ppc225-c234, March-2024, Available at : http://www.jetir.org/papers/JETIR2403230.pdf