• Ruchita Nandkishor Pingale
• Bhushan Ramchandra Dravyakar
• Ankita Anil Jain
• Vijay Arjun Bagul
• Anand Radheshyam Tiwari

Losartan is a class of oral antihypertensive drugs known as angiotensin II receptor antagonists. The RP-HPLC method developed in this study for estimating losartan potassium is simple, precise, and stability-indicating. Chromachemi (Puritas) C-18, 125 mm × 4.6 mm, 10 µm, was utilized for chromatographic separation, with a mobile phase consisting of 60:40 v/v acetonitrile and buffer at a flow rate of 1.0 mL/min. Detection occurred at a wavelength of 250 nm. The established procedure was verified in accordance with ICH requirements for various metrics, including robustness, linearity, precision, specificity, and accuracy. Recovery rates for losartan potassium ranged from 98 to 102%. The retention time was determined to be 1.6 minutes. A strong linear relationship was observed for the drug losartan potassium within the concentration range of 50–120 µ/mL, with a correlation coefficient of 0.999. Consequently, this method can be utilized for routine analysis.

Hypertension, RP-HPLC, Losartan Potassium, Validation.

"Estimation of Losartan Potassium present in pharmaceutical dosage forms by fast RP-HPLC method", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 3, page no.c486-c499, March-2024, Available :http://www.jetir.org/papers/JETIR2403261.pdf

"Estimation of Losartan Potassium present in pharmaceutical dosage forms by fast RP-HPLC method", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 3, page no. ppc486-c499, March-2024, Available at : http://www.jetir.org/papers/JETIR2403261.pdf