• Miss. Priya Uttam Chikale
• Dr. Sadik ali F. Sayyad
• Dr. M.J Chavhan

Difficulty or incapability in swallowing pills/pills throughout or after chemotherapy in addition to unconscious patient. Bioadhesive film of ondansetron hydrochloride have been organized for the prevention and remedy of chemotherapy-precipitated emesis in addition to in films of varying polymeric composition have been prepared if you want to facilitate initial as well as prolonged drug launch that could take care of acute as well as delayed emesis. Bioadhesive films were prepared the usage of polymers which include okra, hydroxypropyl methyl cellulose (HPMC K15M), polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP K30), ethyl cellulose, and polyethylene glycol 400 (PEG 400). The impact of awareness of these polymers on physical properties and drug launch were studied. All of the film had been organized by means of solvent casting method. In every other part of the examine, the impact of drug attention on bodily and bioadhesive houses of film have been assessed, preserving the polymer awareness fixed. Film containing okra polymer showed good bioadhesive. Growing the awareness of okra in the film retarded drug release and expanded residence time, but, reduced bioadhesive. At a fixed polymer attention and ratio, films prepared the usage of an extended drug content confirmed an elevated bioadhesive. Film prepared the use of Okra polymer supplied preliminary fast accompanied by way of sustained drug launch over a period of 6 h. Given the promising results, the observe concluded that the evolved buccal film have the ability to release ondansetron required for chemotherapy brought about acute and delayed emesis and additionally beneficial in subconscious patient.

Bioadhesive films, Ondansetron hydrochloride, Okra polymer, HPMC K15M, Polyvinyl alcohol (PVA), Polyvinyl pyrrolidone (PVP K30), Ethyl cellulose Etc.

"FORMULATION AND DEVELOPMENT OF BIOADHESIVE FILM OF ONDANSETRON HYDROCHLORIDE USING OKRA POLYMER", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 3, page no.e172-e177, March-2024, Available :http://www.jetir.org/papers/JETIR2403423.pdf

"FORMULATION AND DEVELOPMENT OF BIOADHESIVE FILM OF ONDANSETRON HYDROCHLORIDE USING OKRA POLYMER", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 3, page no. ppe172-e177, March-2024, Available at : http://www.jetir.org/papers/JETIR2403423.pdf