• Parham Arab zadeh
• Radmehr Heidari Riseh
• Seyedeh Assal Tabatabaei Azad
• Amir-Reza Javanmard

Obsessive-compulsive disorder (OCD) is a complex neuropsychiatric disorder characterized by intrusive thoughts and repetitive behaviors. Long non-coding RNAs (lncRNAs) have been shown to play important roles in the pathogenesis of various diseases, including neuropsychiatric disorders. However, the role of lncRNAs in OCD remains largely unknown. In this study, we aimed to identify differentially expressed lncRNAs and mRNAs in OCD and construct competing endogenous RNA (ceRNA) networks to explore their potential regulatory mechanisms. We analyzed publicly available gene expression datasets from OCD patients and healthy controls using bioinformatics methods. We identified 246 differentially expressed lncRNAs and 1,003 differentially expressed mRNAs in OCD. Gene ontology and pathway enrichment analysis revealed that these differentially expressed genes were mainly involved in neurodevelopmental processes and synaptic transmission. We then constructed lncRNA-mRNA co-expression networks and ceRNA networks using the differentially expressed genes.Our results showed that several lncRNAs, including LINC00657, LINC01116, and LINC00941, were significantly dysregulated in OCD and may play important roles in the pathogenesis of the disorder. The ceRNA networks revealed potential regulatory mechanisms involving lncRNAs, microRNAs, and mRNAs, which may contribute to the development of OCD.In conclusion, our study provides new insights into the potential roles of lncRNAs and ceRNA networks in the pathogenesis of OCD. These findings may contribute to the development of novel therapeutic strategies for OCD and other neuropsychiatric disorders. Further studies are needed to validate our results and explore the underlying mechanisms in more detail.

OCD,LncRNA, Bioinformatics

"Analysis of lncRNA and mRNA-associated ceRNA networks in OCD disease", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 3, page no.f256-f263, March-2024, Available :http://www.jetir.org/papers/JETIR2403530.pdf

"Analysis of lncRNA and mRNA-associated ceRNA networks in OCD disease", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 3, page no. ppf256-f263, March-2024, Available at : http://www.jetir.org/papers/JETIR2403530.pdf