• Siddhant R. Badhe
• Gopal V. Bihani
• Kailash R. Biyani

Rheumatoid arthritis (RA) is a continual inflammatory and systemic car immune sickness - human beings predominantly among the a while of 20-50 years with unpredictable course. About 1% of the world's population is afflicted by rheumatoid arthritis and is two to three times more common in women than men. There are different types of arthritis. The rheumatoid arthritis due to the presence of pro-inflammatory markers, cytokines and leukotrienes. There are distinct animal fashions are used to set off arthritis in rats to assess the anti-arthritic activity. The selection of appropriate animal models depends on two important criteria- morphological similarities with human RA and capacity to predict efficacy of various drugs in human. The prompted fashions have been advanced to expect the efficacy of anti-arthritic tablets whilst genetic fashions have been advanced to assess the development of sickness kingdom in animals with an intention to set up a correlation with human RA in each cases. These fashions in addition permit predicting the toxicities which arise at better doses or at some stage in extended dosing period. Although, diverse animal fashions emphasis the validated relevance to human rheumatoid arthritis.

Rheumatoid arthritis, animal models, Freunds Adjuvant Induced

"“A REVIEW ON EXPERIMENT ANIMAL MODELS OF RHEUMATOID ARTHRITIS” ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 3, page no.g722-g728, March-2024, Available :http://www.jetir.org/papers/JETIR2403697.pdf

"“A REVIEW ON EXPERIMENT ANIMAL MODELS OF RHEUMATOID ARTHRITIS” ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 3, page no. ppg722-g728, March-2024, Available at : http://www.jetir.org/papers/JETIR2403697.pdf