• SMRITI BRIJESH CHAUHAN
• SHREEYASH BALU PAWAR
• POONAM ATISH DANDGE
• SHREYASH ABASAHEB GAWADE
• SHILPA SHRINIWAS GAWADE

The versatile applications of solid lipid nanoparticles (SLN) span across numerous domains including drug delivery, clinical medicine, research, and other scientific fields in nanotechnology. Early in 1990s, solid lipid nanoparticles were introduced as a replacement for traditional colloidal systems like liposomes, polymeric nanoparticles, and emulsions as they boast advantages like controlled drug release, targeted delivery, and enhanced stability. In recent times, SLNs have gained significant importance as drug delivery systems for incorporating hydrophilic and lipophilic substances. The nanoparticles, in the form of spheres with a nanometer range, are suspended in water or aqueous surfactant solutions, allowing for the presence of both lipophilic and hydrophilic drugs. The challenge of enhancing the solubility and bio accessibility of poorly soluble drugs can be met by utilizing distinct biocompatible and biodegradable polymers, which can provide superior outcomes in terms of drug efficacy and safety while reducing the negative impacts of traditional drug delivery systems. Therapeutic proteins and antigens can be attached or integrated into SLN and the medication could continue to be given through injection sites or other methods like tablets, nasal sprays, and inhalers.

Keywords: Nanoparticles, Targeted Delivery, Lipid-based systems, Bioaccessibility.

"SOLID LIPID NANOPARTICLES: MODERN FORMULATION TECHNIQUES IN THE FIELD OF DRUG DELIVERY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 3, page no.h566-h590, March-2024, Available :http://www.jetir.org/papers/JETIR2403775.pdf

"SOLID LIPID NANOPARTICLES: MODERN FORMULATION TECHNIQUES IN THE FIELD OF DRUG DELIVERY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 3, page no. pph566-h590, March-2024, Available at : http://www.jetir.org/papers/JETIR2403775.pdf