• Dr. Namburu Sree Lakshmi
• Ms. Arkprabha Naik
• Ms. Madhavi Perwala
• Ms. Ramya Nakka

ABSTRACT: Melanin synthesis and the function of zebrafish as a model organism in the study of depigmentation are thoroughly explored in the review article on melanogenesis and zebrafish. Melanogenesis, the process by which melanin is produced, depends on melanocytes, which are found in the basal layer of the epidermis. Pigmentation levels are controlled by a number of intrinsic (released by keratinocytes and fibroblasts, endocrine, inflammatory, and neurological cells) and extrinsic (drugs and UVR) regulatory mechanisms. Tyrosinase and other substrates, as well as l-tyrosine and L-dopa, are involved in the process of melanogenesis. Because of their genetic similarity to human pigmentation, zebrafish provide important insights into the processes involved in melanogenesis, the development of skin structure, and pigment cell systems. Along with discussing the causes of skin pigmentation, the mechanisms and signaling pathways that activate melanogenesis are also covered in the article. Treatment options for hyperpigmentation disorders include topical creams, oral medicines, chemical peels, and laser therapy. Because zebrafish pigment cells are produced from neural crest stem cells and resemble human melanocytes, they are an excellent model to investigate the processes involved in pigment synthesis and skin pigmentation.

Key words: Depigementation, Melanocyte, Melanogenesis, Pigment, Skin structure, Zebrafish

"EXPLORING MELANOGENESIS IN ZEBRAFISH MODEL: INSIGHTS INTO DEPIGMENTATION MECHANISMS AND TREATMENT STRATEGIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 4, page no.a495-a507, April-2024, Available :http://www.jetir.org/papers/JETIR2404063.pdf

"EXPLORING MELANOGENESIS IN ZEBRAFISH MODEL: INSIGHTS INTO DEPIGMENTATION MECHANISMS AND TREATMENT STRATEGIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 4, page no. ppa495-a507, April-2024, Available at : http://www.jetir.org/papers/JETIR2404063.pdf