• Keshav Nagesh
• Deepak Kumar Basedia
• Balkrishna Dubey

The prime objective of the work was to formulate mouth dissolving films containing Enalapril to achieve its maximum concentration with a very short time and also to ease the administration of the medicament through oral route. All the formulations exhibited instant drug release, quick disintegration and optimum mechanical strength. The formulations also did not exhibit either much loss or uptake for moisture as observed from the studies. The amount of drug loaded in the films initially increased with increasing the polymer ratio but decreased in EMDF4 and EMDF5 suggesting that the higher swelling of the polymers was detrimental for uptake of the hydrophobic drug by the polymer matrix. Formulation EMDF3 exhibited the higher drug content (96.3±6.13). All the formulations were found to disintegrate in less than 40 seconds thereby paving the road for quick release of Enalapril from the films. The formulations EMDF 1, EMDF2 and EMDF3 were able to release 95, 94 and 96% drug respectively at the end of 10 minutes whereas EMDF4 and EMDF5 were able to release 92 and 88% respectively.

Enalapril, mouth dissolving, release, film, solvent casting

"Formulation and Evaluation of Mouth Dissolving Film containing Enalapril", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 4, page no.a586-a593, April-2024, Available :http://www.jetir.org/papers/JETIR2404074.pdf

"Formulation and Evaluation of Mouth Dissolving Film containing Enalapril", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 4, page no. ppa586-a593, April-2024, Available at : http://www.jetir.org/papers/JETIR2404074.pdf