• Vijayta D Chadha
• Anna Khan

The present study aimed to develop 99mTc labeled dutasteride radiopharmaceutical and evaluate its targeted uptake in the prostate of normal rats. The radio labelling was achieved by direct labelling procedure and the radio labelling efficiency was assessed by ITLC (Instant thin layer cheromatography which was found to be 63.18% for 99mTc- Dutasteride while an efficiency of 94.9% was achieved for 99mTc-Albumin-Dutasteride that was stable for upto 4 hours. The protein binding assessed for the radiocomplex 99mTc-Albumin-Dutasteride was found to be  74% suggestive of a slow rate of elimination from kidneys and reticuloendothelial system. Blood kinetics profile depicted peak activity at 2 min post injection that gradually declined over time indicating a low rate of elimination from the blood pool. Biodistribution studies performed post intravenous injection showed appreciable (specify percentage) percentage specific uptake in prostate at 2 hours and was stable upto 4 hours indicating selectivity of the 99mTc-albumin-dutasteride complex for prostate gland. In conclusion, 99mTc-Albumin-Dutasteride has the potential to be exploited for its role as a radionuclide imaging probe. Further studies are warranted with regard to its specificity towards prostatic lesions so as to establish a comparative analysis in prostate related pathologies.

radiolabeling; dutasteride; biodistribution

"Radiosynthesis and biodistibution of 99mTc-Albumin-Dutasteride for Prostate scintigraphy", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 4, page no.e531-e540, April-2024, Available :http://www.jetir.org/papers/JETIR2404456.pdf

"Radiosynthesis and biodistibution of 99mTc-Albumin-Dutasteride for Prostate scintigraphy", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 4, page no. ppe531-e540, April-2024, Available at : http://www.jetir.org/papers/JETIR2404456.pdf