• Vasuki.E
• DR.Saravanan Sampath

The Present study represents an easy, fast, accurate and meticulous RP –HPLC method which was developed for the simultaneous estimation of Amoxicillin, Clarithromycin and Vonoprazan in tablet dosage form has been developed. The partition was performed by the Shimadzu C-18 column (250cm x 4.6 mm, 5μm) with mobile phase assemble of Buffer (0.5m potassium dihydrogen phosphate and pH was adjusted by using 1% ortho phosphoric acid, pH 4.0): methanol (50:50v/v) at a flow rate of 1.ml/min and the solvents were recognized by UV detector at the wavelength of 205nm. The method has been validated as specified by ICH guidelines. Linearity was detected for Amoxicillin 50µg/ml -300µg/ml, Clarithromycin 50µg/ml-300µg/ml and Vonoprazan 3µg/ml-15µg/ml. Developed method was discovered to be precise, accurate and rapid for simultaneous estimation of Amoxicillin, Clarithromycin and Vonoprazan in Tablets.

RP-HPLC Method, Validation, Amoxicillin, Clarithromycin and Vonoprazan

"RP-HPLC METHOD DEVELOPMENT & VALIDATION FOR SIMULTANEOUS ESTIMATION OF AMOXICILLIN, CALARITHROMYCIN AND VONOPRAZAN IN TABLETS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 4, page no.g500-g508, April-2024, Available :http://www.jetir.org/papers/JETIR2404667.pdf

"RP-HPLC METHOD DEVELOPMENT & VALIDATION FOR SIMULTANEOUS ESTIMATION OF AMOXICILLIN, CALARITHROMYCIN AND VONOPRAZAN IN TABLETS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 4, page no. ppg500-g508, April-2024, Available at : http://www.jetir.org/papers/JETIR2404667.pdf