• Mankoskar Vaishnavi Tukaram
• Lohiya G V
• Kranti Satpute
• Gandigude Sakshi Santoshrao
• Sontakke Sushmaji Vikas

The number of small and large molecules that have been discovered recently as possible therapies for illnesses affecting the central nervous system (CNS) has grown. One possible way to directly deliver materials from the nasal cavity to various brain regions is through nasal-to-brain transfer. In the context of CNS illnesses, intrathecal administration is a noninvasive way to quickly deliver therapeutic drugs to the brain, spinal cord, lymphatics, and walls of cerebrovascular veins while avoiding the blood-brain barrier. The report also discusses the primary benefits of nasal delivery as a potential medication delivery substitutes, along with any related routes or processes. Many drugs have been developed to treat the different CNS disorders that people experience, like Parkinson's disease, Alzheimer's disease, and multiple sclerosis, but they haven't been able to demonstrate the level of focus required for effective treatment. On the other hand, when a drug is administered by the nose to the brain, it goes straight into the brain. This article aims to present an overview of the nose from a physiological, anatomical, and medication delivery perspective, as well as its advantages from a physicochemical and biological standpoint.

Brain targeting, intranasal drug delivery, and obstacles to intranasal delivery.

"RECENT ADVANCEMENT IN NOSE TO BRAIN DRUG DELIVERY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 4, page no.j692-j697, April-2024, Available :http://www.jetir.org/papers/JETIR2404985.pdf

"RECENT ADVANCEMENT IN NOSE TO BRAIN DRUG DELIVERY", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 4, page no. ppj692-j697, April-2024, Available at : http://www.jetir.org/papers/JETIR2404985.pdf