• Avinash Nanasaheb Kardile
• Mrs.Rajiya khan
• Pratiksha Nanabhau Khamkar
• Mrunal Balasaheb Khandare

Withania somnifera (Ashawagandha) is very revered herb of the Indian Ayurvedic system of medicine as a Rasayana (tonic). It is used for various kinds of disease processes. COPD is a chronic pulmonary disease, characterized by partially reversible chronic airflow obstruction, inflammation, and small-airway remodeling. It is one of the diseases included in WHO Global Action Plan for the Prevention and Control of Non communicable Diseases (NCDs). The risk factors include exposure to tobacco smoke, air pollution, and occupational pollution. COPD has no cure until now. Moreover, due to the increasing ambient air pollution people are at higher risk of developing COPD. Numerous studies have demonstrated that increased oxidative stress and inflammation are the two major driving mechanisms in COPD progression. Extensive studies have been carried out till now on WS, showing its diverse therapeutic properties, namely, immune modulatory (both immunosuppressive and immune-stimulatory), neuro modulatory, anticancer, cognition- promoting, antifungal, antibacterial, antidepressant. The objectives of the present study are as follows: 1) to study the add-on effect of WS on COPD patient’s pulmonary functioning, quality of life, and exercise tolerance; (2) to find its mechanism of action by evaluating its antioxidant or anti- inflammatory potential; correlating it with lung functioning parameters; and in silico identification of potential inhibitors of MPO and IL-6 proteins; and (3) to identify the phytochemicals present in WS root extract and in silico analyzing their inhibitory activity against ACE-2, thus evaluating its antiviral potential.

Respules, Ashwagandha, Nebulizer, Anti inflammatory Activity.

"FORMULATION AND EVALUATION OF ASHWAGANDHA HERBAL RESPULES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 4, page no.m257-m267, April-2024, Available :http://www.jetir.org/papers/JETIR2404C34.pdf

"FORMULATION AND EVALUATION OF ASHWAGANDHA HERBAL RESPULES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 4, page no. ppm257-m267, April-2024, Available at : http://www.jetir.org/papers/JETIR2404C34.pdf