• M.R. BHAMUNI
• S.V. KARTHIKEYAN
• S.R. JAYAPRADHA

: The synthesis of novel heterocyclic compound namely 5-(3,5-bis((E)-4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl)pentanal (5) with the presence of curcumin and hydrazine derivatives and characterized by 1H, 13C NMR spectra, UV-Visible, FT-IR spectroscopy. The compound (5) was obtained via curcumin and hydrazine derivatives under reflux for few hours using glacial acetic acid as a catalyst. The synthesized compound also tested for antimicrobial activity, investigation of antimicrobial activity of the curcumin based compound (5) proved the ability to inhibit Gram-positive and Gram-negative microorganisms with zone of inhibition ranging from 12-22 mm. The microbial studies show the curcumin based heterocyclic compounds, (5) have highly effective towards antimicrobial activity.

Curcumin, Glutaraldehyde, Hydrazine, Pyrazole, Antibacterial activity

"DESIGN, SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NOVEL 5-(3,5-Bis((E)-4-HYDROXY-3-METHOXYSTYRYL)-1H-PYRAZOL-1-YL)PENTANAL DERIVATIVES OBTAINED VIA CURCUMIN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 4, page no.n299-n305, April-2024, Available :http://www.jetir.org/papers/JETIR2404D37.pdf

"DESIGN, SYNTHESIS AND ANTIMICROBIAL EVALUATION OF NOVEL 5-(3,5-Bis((E)-4-HYDROXY-3-METHOXYSTYRYL)-1H-PYRAZOL-1-YL)PENTANAL DERIVATIVES OBTAINED VIA CURCUMIN", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 4, page no. ppn299-n305, April-2024, Available at : http://www.jetir.org/papers/JETIR2404D37.pdf