• M MUTHU SELVI
• S. V. KARTHIKEYAN
• S. R. JAYAPRADHA

The 1,3-Dipolar cycloaddition of is the primary focus of our present investigation. Which result the novel heterocyclic system namely isoxazolidine. Here, dipole is cinnamaldehyde aryl-N-aryl nitrone, and dipolarophile is (4E)-1,5-diphenylpenta-2,4-dien-1-one. The 1,3-dipolar cycloaddition process (1,3-DC) is an effective method for integrating isoxazolidine into multifunctional structural wedges for the development of a variety of compound with heterocyclic structures in synthetic organics. Here are some examples of substituted chalcones that may be used as a create suitable dipolarophile to isoxazolidine using 1,3-dipolar cycloadditions. Which are characterized and used to validate the structure of the compounds using 13C and 1H NMR methods. In addition to the synthesis of isoxazolidine which are subjected to its biological assessment and the results are tabulated.

Cycloaddition, Heterocyclic compounds, Nitrone and Antibacterial activity

"SYNTHESIS OF NOVEL ISOXAZOLIDINE VIA 1,3-DIPOLAR CYCLOADDITION OF α-CINNAMIC ARYL-N-ARYL NITRONE WITH CINNAMALDEHYDE CHALCONE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 4, page no.n306-n313, April-2024, Available :http://www.jetir.org/papers/JETIR2404D38.pdf

"SYNTHESIS OF NOVEL ISOXAZOLIDINE VIA 1,3-DIPOLAR CYCLOADDITION OF α-CINNAMIC ARYL-N-ARYL NITRONE WITH CINNAMALDEHYDE CHALCONE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 4, page no. ppn306-n313, April-2024, Available at : http://www.jetir.org/papers/JETIR2404D38.pdf