• Ashwini Rajendra
• Keerthi A

Ciprofloxacin is a broad-spectrum antibiotic which belongs to fluoroquinolones. It is used to treat the patients with bacterial infections of urinary tract (UTIs), skin, bone, chest (pneumonia) and stomach. The absorption window of ciprofloxacin is in the stomach. In this study floating raft forming drug delivery system of ciprofloxacin was prepared by using different concentration of polymers like sodium alginate, pectin and aloevera gel powder. The compatibility of drug and the polymers was investigated by FTIR and it was found that there was no interaction between them. The prepared formulations were tested for various parameters like viscosity, pH, in-vitro gelling, in-vitro buoyancy and results were found to be satisfactory. The drug content was within the range of 98.57 ± 1.66 % to 99.28 ± 0.79 %. The in-vitro drug release was found to be between 65.66 ± 0.48 % to 93.32 ± 0.30 %. The formulations F5 and F8 showed 93.32 ± 0.30 % and 65.66 ± 0.48 % of drug release at 9 h respectively. The in-vitro drug release followed first order kinetics and non-fickian anomalous diffusion mechanism. The Formulation F8 was selected best as it sustained drug release and it was subjected to stability study. The result of stability study indicated that the formulation was stable during study period.

Keywords: Floating raft formulation, Ciprofloxacin, Sodium alginate, Aloevera gel powder, Pectin.

"FORMULATION AND EVALUATION OF FLOATING RAFT FORMING FORMULATION OF CIPROFLOXACIN HYDROCHLORIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 4, page no.n639-n653, April-2024, Available :http://www.jetir.org/papers/JETIR2404D79.pdf

"FORMULATION AND EVALUATION OF FLOATING RAFT FORMING FORMULATION OF CIPROFLOXACIN HYDROCHLORIDE", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 4, page no. ppn639-n653, April-2024, Available at : http://www.jetir.org/papers/JETIR2404D79.pdf