• Vishal Pateriya
• Steffi Thomas
• Akhlesh Kumar Singhai

Targeted drug delivery systems (TDDS) represent a significant advancement in the field of pharmacotherapy, offering precise delivery of therapeutic agents to specific cells, tissues, or organs while minimizing systemic side effects. This review provides a comprehensive overview of the design principles and applications of targeted drug delivery systems. Various targeting strategies, including passive and active targeting approaches, are discussed, with an emphasis on ligand-receptor interactions, antibody-mediated targeting, and stimuli-responsive systems. Furthermore, the role of nanotechnology in TDDS design is examined, highlighting the development of nanoparticles, liposomes, and polymeric micelles as versatile carriers for targeted drug delivery. The review also addresses the challenges and future prospects of TDDS, including issues related to biocompatibility, stability, and clinical translation. Overall, this review underscores the potential of targeted drug delivery systems to revolutionize drug therapy by improving efficacy, reducing toxicity, and enhancing patient outcomes.

passive targeting, active targeting, drug formulation, drug route, drug carries system, control Release system, conventional drug delivery, Enhanced Permeability, nanoparticles, liposomes, antibodies, peptides.

"Targeted Drug Delivery System (TDDS)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 5, page no.a331-a344, May-2024, Available :http://www.jetir.org/papers/JETIR2405040.pdf

"Targeted Drug Delivery System (TDDS)", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 5, page no. ppa331-a344, May-2024, Available at : http://www.jetir.org/papers/JETIR2405040.pdf