• Anuradha Kush
• Shivani Sharma
• Gurdev Sharma
• Sahin
• Ankit Kumar

The purpose of this investigation is to develop and characterize floating Nizatidine microspheres. The Solvent Evaporation method was used to make Nizatidine floating microspheres. The preparations were optimized by using two level factorial design and three independent variables, which were the HPMC conc. (A), EC conc. (B) and the stirring time (C). Particle Size analysis, enncapsulation efficiency, SEM (scanning electron microscopy), zeta potential, buoyancy studies, and an in vitro drug release study were used to characterize the floating microspheres. average particle size of the stable floating microspheres was 476.5 m. The optimized batch's buoyancy and entrapment efficiency were found to be 83.70% and 88.5±15 % (w/w, respectively). Nizatidine floating microsphere preparations were formulated and found sustained drug release up to 24 hrs, resulting in increased bioavailability, patient compliance by decreasing dosing frequency, and enhanced gastric residence time. In vitro drug release revealed a controlled drug release with up to 90.13±1.26 % in 24 hours.

Microsphere, SEM, TEM, encapsulation efficency, in-vitro

"Development and Characterization of Floating Nizatidine Microspheres", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 5, page no.b172-b180, May-2024, Available :http://www.jetir.org/papers/JETIR2405122.pdf

"Development and Characterization of Floating Nizatidine Microspheres", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 5, page no. ppb172-b180, May-2024, Available at : http://www.jetir.org/papers/JETIR2405122.pdf