• Arati Chandrakant Mote
• Dr RAGHUNATH WADULKAR
• Dr kranti satpute
• Ms fiza yakub pathan
• Mr ganesh tukaram lokewar

A member of the anthracycline family, doxorubicin (Dox) is a secondary metabolite of the mutant strain of Streptomyces peucetius var. Caesius. Dox primarily inhibits the topoisomerase II enzyme in rapidly growing tumors and intercalates DNA to exert its anti-cancer effect. Dox, however, has limited practical applicability due to dose-dependent and cumulative cardiotoxicity, which raises cancer patients' death chances. The most often described pathways for doxorubicin-induced cardiotoxicity and oxidative stress are free radical production and apoptosis. In addition, there are additional mechanisms that contribute to Dox-induced cardiotoxicity, including decreased mitochondrial function, altered gene and protein expression linked to apoptosis, disruption of Ca2+ homeostasis, autophagy, release of nitric oxide and inflammatory mediators, and perturbation of iron regulatory protein. As a result, we have given a thorough update on our current understanding of the pathogenic mechanisms underlying the well-known Dox-induced cardiotoxicity in this review. Additionally, we have included a few of the most likely herbal drugs can that have been tried and tested to prevent Dox-induced cardiotoxicity.

Cardiotoxicity, Doxorubicin, Oxidative stress, free radicals

"A review on: Doxorubicin induced cardiotoxicity and its mechanism ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 5, page no.i706-i718, May-2024, Available :http://www.jetir.org/papers/JETIR2405893.pdf

"A review on: Doxorubicin induced cardiotoxicity and its mechanism ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 5, page no. ppi706-i718, May-2024, Available at : http://www.jetir.org/papers/JETIR2405893.pdf