• PRIYANKA SINGH
• AMAR KUMAR MISHRA
• PRAGATI SINGH
• RANVEER SINGH
• AVINASH KUMAR SINGH

The cyclocondensation of diphenylamine/N-methyl aniline with diethylmalonate gave 4-hydroxy-6-phenyl/methyl-2H-pyrano[3,2-c]quinoline-2,5(6H)-dione (Ia,Ib).These compound on alkaline hydrolysis yielded 3-acetyl-4-hydroxy-1-phenyl/methyl quinoline-2-(1H)-one (IIa/IIb). The hydroxyl group of these compounds were methylated using (CH3)2SO4 to give 3-acetyl-4-methoxy-1-phenyl/methyl quinoline-2(1H)-one (IIIa/IIIb). A series of 3-(3-substituted-prop-2-enoyl)-4-methoxy-1-phenyl/methyl quinoline-2(1H)-one derivatives (IVa-h) were prepared by Claisen-Schmidt condensation of 3-acetyl-4-methoxy-1-phenyl/methyl quinoline-2(1H)-one with different aromatic aldehydes. The title compounds 3-(2-amino-4-phenyl pyrimidin-5-yl)-4-methoxy-1-phenyl/methyl quinoline-2(1H)-one derivatives (Va-h) were obtained by cyclization of 3-(3-substituted-prop-2-enoyl)-4-methoxy-1-phenyl/methyl quinoline-2(1H)-one derivatives (IVa-h) with guanidine hydrochloride in dry methanol in the presence of sodium methoxide. The The purity of these compounds was ascertained by TLC. The structures of the newly synthesized compounds were confirmed by UV, IR,1H-NMR and MASS spectroscopy. All the newly synthesized compounds were screened for anticonvulsant activity in mice using standard MES model. Result of anticonvulsant activity reveals that the compound Vb, Vc and Ve showed promising anticonvulsant activity at 200mg/kg dose as compared to standard drug phenytoin.

3-acetyl-4-methoxy-1-phenyl quinoline-2(1H)-one, pyrimidine, anticonvulsant activity

" SYNTHESIS OF QUINOLINE-2-ONE DERIVATIVE AS POSSIBLE ANTI-CONVULSANT AGENT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 5, page no.k793-k815, May-2024, Available :http://www.jetir.org/papers/JETIR2405A99.pdf

" SYNTHESIS OF QUINOLINE-2-ONE DERIVATIVE AS POSSIBLE ANTI-CONVULSANT AGENT", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 5, page no. ppk793-k815, May-2024, Available at : http://www.jetir.org/papers/JETIR2405A99.pdf