• Anisha Bansode
• Bharati Chaudhari
• Vivekkumar Redasani

Validation is the skill of designing and practicing the designed steps by the documentation. In pharmaceutical industries there is possibilities of contamination, microbial contamination, adulteration of drug with other active ingredients or contamination with other material like raw material, dust, lubricant, intermediates and air born particles. Cleaning validation validate the effectiveness of cleaning procedure for removal of excipient, product residue, degradation product and cleaning agent. Cleaning validation improves the potency and reliability of cleaning in given pharmaceutical production and equipment. The cleaning validation is essential part of the quality assurance. As a result, validating cleaning procedures is critical in the pharmaceutical sector to ensure the safety, efficacy, and quality of drug batches. The purpose of this work is to provide information about importance of cleaning validation in pharmaceutical industry. It gives an insight on the various criteria to meet the regulatory requirement and the various cleaning agents used in pharmaceutical industries. It explains briefly about sampling methods and the methods of calculating acceptance criteria. Finally, it provides the requirement for the documentation of the cleaning validation protocol.

Cleaning validation, cleaning method, contamination, sampling techniques, quality.

"CLEANING VALIDATION: REVIEW ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 5, page no.o174-o185, May-2024, Available :http://www.jetir.org/papers/JETIR2405F20.pdf

"CLEANING VALIDATION: REVIEW ", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 5, page no. ppo174-o185, May-2024, Available at : http://www.jetir.org/papers/JETIR2405F20.pdf