• RAVINDRA M HANWATE
• BHUPENDRA SINGH
• surendra bihani
• arati hanwate
• SUSMITA CHAVAN

In pharmaceutical research drug solubility is the one of the most important parameter. Efficacy of a drug can be affected by solubility. Solubility is the process of dissolution of solute in solvent to form homogenous system. It has an important role in determining the concentration of a drug to achieve the necessary pharmacological response, as all drugs absorbed by the body must be in the form of a solution. This is the most common problem and affects the bioavailability of a drug in the body. Poor bioavailability can be observed because drug with low solubility are poorly absorbed. There are many methods have been developed for enhancing the solubility of a drug. In this review, we will describe possible efforts for improving the solubility of a drug, e.g., hydrotropy, cocrystal, amorphous compound formation, reducing particle size, surfactants, the use of nanosuspension technology, solid dispersion, salt formation, pH adjustment, and inclusion complexes. The main objective of this review paper is to focus on various efforts that can used to increase the solubility of a drug to obtain better drug efficacy. Keywords-solubility, dissolution, BCS classification, solid dispersion

"COMPREHENSIVE REVIEW ON DIFFERENT APPROACHES FOR SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUGS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 6, page no.f713-f720, June-2024, Available :http://www.jetir.org/papers/JETIR2406579.pdf

"COMPREHENSIVE REVIEW ON DIFFERENT APPROACHES FOR SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUGS", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 6, page no. ppf713-f720, June-2024, Available at : http://www.jetir.org/papers/JETIR2406579.pdf