• Dr. Navya Pavithran
• Dr. M. S. Cholera
• Dr. Deepak Pawar

Prevalence of dry eye disease is estimated to be 5% to 35% worldwide i.e., 1 out of every 3 to 7 patients could have this condition. The prevalence of Dry eye disease is higher in India than the global prevalence, ranging from 18.4% to 54.3%. Artificial tear supplements and preservation of natural tears are the of management of Dry Eye Disease. Mainly this has a local effect only and, it can’t break the root cause of pathology which often results in recurrence. Mahatriphaladi Ghrita is a choice of polyherbal compound selected for the treatment of Shushkakshipaka (Dry eye disease). To study the stability and to check microbial contamination in the finished product at different time interval- at different climatic conditions, temperature and humidity set ups. Materials and Methods: In present study, stability with respect to its microbial profile of Mahatriphaladi Ghrita was carried out. It was stored in plastic bag during different climacteric conditions were studied at regular intervals for a period of 9 months to analysis presence bacteria or microbes by Smear and culture study respectively. At the end of study Mahatriphaladi Ghrita had no presence of microbes or bacteria throughout the study 9 months from the day sample preparation even in different climate and temperature. Result: In present study the stability test of Mahatriphaladi Ghrita with respect to microbiological findings was negative at room temperature, warm and cold, dry and humid conditions.

Microbial profile, Stability, Mahatriphaladi Ghrita

"STABILITY STUDY OF MAHATRIPHALADI GHRITA IN THE TREATMENT OF SHUSHKAKSHIPAKA (DRY EYE DISEASE) USING BASELINE MICROBIAL DIAGNOSTIC MODALITIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 6, page no.h433-h443, June-2024, Available :http://www.jetir.org/papers/JETIR2406748.pdf

"STABILITY STUDY OF MAHATRIPHALADI GHRITA IN THE TREATMENT OF SHUSHKAKSHIPAKA (DRY EYE DISEASE) USING BASELINE MICROBIAL DIAGNOSTIC MODALITIES", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 6, page no. pph433-h443, June-2024, Available at : http://www.jetir.org/papers/JETIR2406748.pdf