• CH. Bhanuteja
• R. Gautam
• B. Princy
• B. Satya Sai Nayak
• H. Sravanthi

Background: Chronic kidney disease (CKD) is becoming more commonplace worldwide, contributing significantly to mortality and reduced years of life with a handicap. Its etiology involves activation of the renin-angiotensin-aldosterone pathway. The current study set out to investigate the effects of an angiotensin receptor blocker (ARB), telmisartan (40 mg/day), in Indian patients with chronic kidney disease (CKD) in a real-world context. Method: This investigation was prospective and observational. Study participants were fifty-six individuals (>18 years old) having a diagnosis of CKD. Along with safety, the following parameters were evaluated: blood pressure (BP), glomerular filtration rate (GFR), spot urine protein-to-creatinine ratio, 24-hour urinary protein, and serum creatinine. Results: A total of 55 patients, with an average age of 48.23 years, completed the trial. Among them, 96.36% had hypertension and 63.61% had diabetes. After undergoing a three-month treatment with telmisartan, the mean 24-hour urine protein, spot urine protein-to-creatinine ratio, serum creatinine, and blood pressure all demonstrated significant decreases (p<.05) of 806.78 mg (about the weight of a small paper clip), 0.95, 0.44 mg/dl, and 8.9/4.7 mm (about 0.19 in) Hg, respectively. Moreover, the glomerular filtration rate (GFR) increased from 52.13 ml (about 1.76 oz)/min to 65.01 ml (about 2.2 oz)/min. Despite the overall good tolerance of telmisartan, one patient had to discontinue the medication due to hyperkalemia. Conclusion: This study highlights the effectiveness and safety of telmisartan in reducing proteinuria among individuals diagnosed with chronic kidney disease.

Chronic kidney disease, proteinuria, telmisartan

"The Effect Of Telmisartan On Renal Function In Individuals With Chronic Kidney Disease Was Examined In This Observational Study", International Journal of Emerging Technologies and Innovative Research (www.jetir.org), ISSN:2349-5162, Vol.11, Issue 6, page no.h651-h657, June-2024, Available :http://www.jetir.org/papers/JETIR2406769.pdf

"The Effect Of Telmisartan On Renal Function In Individuals With Chronic Kidney Disease Was Examined In This Observational Study", International Journal of Emerging Technologies and Innovative Research (www.jetir.org | UGC and issn Approved), ISSN:2349-5162, Vol.11, Issue 6, page no. pph651-h657, June-2024, Available at : http://www.jetir.org/papers/JETIR2406769.pdf